Peri-implantitis is an inflammatory process caused by a biofilm forming around dental implants inducing bone loss around the dental implant. Thus it is important to inhibit the biofilm formation on dental implant surface. The aim of this study was to evaluate the inhibition of biofilm formation and osteoblast activation on non-thermal plasma-treated TiO2 nanotubes.
Electrochemical anodization was used to grow TiO2 nanotubes on commercially pure Ti discs followed by heat treatment and non-thermal atmospheric pressure plasma treatment. Surface properties, inhibition of biofilm formation as well as MC3T3-E1 cell adhesion, proliferation and differentiation were evaluated.
Heat treatment of TiO2 nanotubes inhibited adhesion of S. mutans which related to initial biofilm formation. Plasma treatment on TiO2 nanotubes inhibited the adhesion of P. gingivalis which is associated with periimplantitis. Heat and plasma treatment on TiO2 nanotube promoted proliferation and differentiation of MC3T3-El cell.
This work was supported by the National Research Council of Science & Technology (NST) grant by the Korea government (MSIT) (No. CRC-15-03-KIMM).