Nature inspired submicro-structured surfaces provide the unique functionality such as surface wetting from super-hydrophilic to super-hydrophobic. Since the wetting characteristics control the condensation of water on surface, the surface functionality can induce either filmwise or dropwise form of water. Based on the type of water condensation formation, the heat exchange could be affected. The condensed water affects on the temperature difference between front and back of surface while one side of surface wets. In this work, we used two types of polymer film of different thermal conductivity with fixed thickness (50 μm in our case). The effect of the relation between the wettability and thermal conductivity was experimentally quantified by gas to gas heat exchange system. In dry condition, high thermal conductive film has lower temperature difference than low thermal conductive film on heat exchange. For wet condition, Wettability is one of the main factors and it has critical effect for design micro size heat exchanger. This study is able to expected to provide the new platform to design the polymer heat exchanger with simple and versatile method for advanced material and functional devices