The functional significance rather than conventional evaluation by geometric lumen area reduction of coronary stenosis has recently received much attention. Hemodynamics based diagnostic parameters such as fractional flow reserve (FFR) and wall shear stress (WSS) are most representative physiological indices for identifying lesion severity. Previous studies demonstrated superior performance of FFR and WSS to identify ischemia-causing coronary stenosis.
These hemodynamic parameters are closely related to blood flow characteristics downstream of stenosis which is greatly affected by geometric shape of stenosis.
Although the in vivo geometry of stenosis is irregular and complex, we extracted major feature geometric parameters and investigate the effect on the FFR and WSS.
In this study, we carried out 3D computational fluid dynamics simulations for coronary artery models with considering various stenosis geometric parameters and performed correlation analysis.