This paper proposes a method to generate the movement of blood vessel results from the motion of heart in the real-time angiography simulation. The displacements of the blood vessel in three dimensions are obtained by matching the displacements of the blood vessel on the actual angiography images captured at two different camera angles. The displacements of each point are mapped to the corresponding points of simulation model with the similar structure. The rendered blood vessel is translationally moved on the image rendering plane according to the information of three-dimensional displacement. The proposed method generates similar movement of the blood vessel with the actual angiography images. An average computation time is 6.05 ms for each frame.