The multiphysics simulation is an important subject for a very wide variety of scientific and engineering applications. Computational complications in the involved physical theories have introduced novel ideas based on in-depth understandings towards physics and many numerical analysis procedures. Depending on differences in the manner of computational coupling, these analysis procedures can be categorized as either staggered or monolithic analysis procedures . Additionally, many studies can be found with regard to size and shape structural optimization methods for multiphysics systems, and there are some topology optimization studies for topological alternations or connectivity alternations inside multiphysics domains. In the present study, several structural optimization researches for FSI, acoustic and structure will be presented.